TEAD4 antagonizes cellular senescence by remodeling chromatin accessibility at enhancer regions.

ABSTRACT: Dramatic alterations in epigenetic landscapes are known to impact genome accessibility and transcription. Extensive evidence demonstrates that senescent cells undergo significant changes in chromatin structure; however, the mechanisms underlying the crosstalk between epigenetic parameters and gene expression profiles have not been fully elucidated. In the present study, we delineate the genome-wide redistribution of accessible chromatin regions that lead to broad transcriptome effects during senescence. We report that distinct senescence-activated accessibility regions (SAAs) are always distributed in H3K27ac-occupied enhancer regions, where they are responsible for elevated flanking senescence-associated secretory phenotype (SASP) expression and aberrant cellular signaling relevant to SAS

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10587282 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature