Programmed death-ligand 1 (PD-L1) expression in primary gastric adenocarcinoma and matched metastases.

ABSTRACT:

Background

Combination of immunotherapy and chemotherapy is recommended for first line treatment of gastric adenocarcinoma (GC) patients with locally advanced unresectable disease or metastatic disease. However, data regarding the concordance rate between PD-L1 combined positive score (CPS) in primary GC and matched regional lymph node metastasis (LNmet) or matched distant metastasis (Dmet) is limited.

Methods

Tissue microarray sections from primary resected GC, LNmet and Dmet were immunohistochemically stained with anti-PD-L1 (clone SP263). PD-L1 expression was scored separately in tumour cells and immune cells and compared between matched primary GC, LNmet and/or Dmet. CPS was calculated and results for CPS cut-offs 1 and 5 were compared between matched samples.

Results

SUBMITTER: Liu DHW 

PROVIDER: S-EPMC10587283 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature