Evaluation of ceftriaxone pharmacokinetics in hospitalized Egyptian pediatric patients.

ABSTRACT: This study aimed to evaluate ceftriaxone pharmacokinetics that affects the achievement of targets in the treatment of critically ill children (meningitis, pneumonia, urinary tract infection, peritonitis, and infective endocarditis( who were admitted to Zagazig University Pediatric hospital in Egypt to monitor for the drug adverse effects.Blood samples were obtained from 24 hospitalized pediatric patients (ages ranging from 2.5 months to 12 years) after administering the calculated dose of ceftriaxone via intravenous bolus route. Then, ceftriaxone plasma concentrations were measured using a validated HPLC method with ultraviolet detection. The pharmacokinetic analysis was conducted using Phoenix Winnonlin Program^® software.Data for total and free ceftriaxone best fitted on a one-

SUBMITTER: Eldougdoug MW 

PROVIDER: S-EPMC10587312 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature