Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease.

ABSTRACT:

Introduction

Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed.

Methods

We assessed the diagnostic performance of p-tau₁₈₁ , p-tau₂₁₇ , and p-tau₂₃₁ in plasma and CSF in 174 individuals evaluated by dementia specialists and assessed with amyloid-PET and tau-PET. Receiver operating characteristic (ROC) analyses assessed the performance of plasma and CSF biomarkers to identify amyloid-PET and tau-PET positivity.

Results

Plasma p-tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p-tau. Plasma p-tau₁₈₁ (AUC = 76%) and p-tau₂₃₁ (AUC = 82%) assessments performed inferior to CSF p-tau₁₈₁ (AUC = 87%) a

SUBMITTER: Therriault J 

PROVIDER: S-EPMC10587362 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature