Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans.

ABSTRACT: Ketones are alternative energy substrates for the heart and kidney but no studies have investigated their metabolism simultaneously in both organs in humans. The present double tracer positron emission tomography (PET) study evaluated the organ distribution and basal kinetic rates of the radiolabeled ketone, ¹¹C-acetoacetate (¹¹C-AcAc), in the heart and kidney compared to ¹¹C-acetate (¹¹C-Ac), which is a well-validated metabolic radiotracer. Both tracers were highly metabolized by the left ventricle and the renal cortex. In the heart, kinetic rates were similar for both tracers. But in the renal cortex, uptake of ¹¹C-Ac was higher compared to ¹¹C-AcAc, while the reverse was observed for the clearance. Interestingly, infusion

SUBMITTER: Cuenoud B 

PROVIDER: S-EPMC10587428 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature