Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics.
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ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC10587531 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Identification of immune-related genes for the diagnosis of ischemic heart failure based on bioinformatics.
Yu Yiding Y Liu Xiujuan X Xue Yitao Y Li Yan Y
iScience 20231004 11
The role of immune cells in the pathogenesis of ischemic heart failure (IHF) is well-established. However, identifying key genes in patients with IHF remains a challenge. We obtained two IHF datasets from the GEO database (GSE76701 and GSE21610), and identified four potential diagnostic candidate genes for IHF by using bioinformatics and machine learning algorithms, namely RNASE2, MFAP4, CHRDL1, and KCNN3. We constructed nomogram and validated the diagnostic value of these genes on additional GE ...[more]
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