Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor.

ABSTRACT:

Introduction

In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with essential tremor (ET) and Parkinson's disease (PD).

Methods

We enrolled 16 patients with ET, 17 with PD, and 18 healthy controls (HC). Each participant underwent comprehensive clinical evaluations, kinematic assessments of finger tapping. ET and PD patients underwent DAT-SPECT imaging. The DAT-SPECT scans were subjected to both visual and semi-quantitative analysis using DaTQUANT®. We then investigated the correlations between the clinical, kinematic, and DAT-SPECT data, in patients.

Results

Our findings confirm that individuals with ET exhib

SUBMITTER: Colella D 

PROVIDER: S-EPMC10587600 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature