Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device - a narrative review.

ABSTRACT: Arthritic disorders have become one of the main contributors to the global burden of disease. Today, they are one of the leading causes of chronic pain and disability worldwide. Current therapies are incapable of treating pain sufficiently and preventing disease progression. The lack of understanding basic mechanisms underlying the initiation, maintenance and progression of arthritic disorders and related symptoms represent the major obstacle in the search for adequate treatments. For a long time, histological evaluation of joint pathology was the predominant outcome parameter in preclinical arthritis models. Nevertheless, quantification of pain and functional limitations analogs to arthritis related symptoms in humans is essential to enable bench to bedside translation and to evaluate the

SUBMITTER: Ritter J 

PROVIDER: S-EPMC10587608 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature