In Vivo Visualization and Quantification of Optic Disc Microvasculature for Assessing Renal Dysfunction.

ABSTRACT:

Objective

To assess the relationship between optic disc microvasculature and renal function in subjects with diabetes mellitus without diabetic retinopathy (DR).

Design

Prospective, cross-sectional study.

Participants

A total 1629 patients with type 2 diabetes mellitus without DR were recruited from the community of Guangzhou, China.

Methods

All subjects underwent 6 mm × 6 mm OCT angiography (OCTA) centered on the optic nerve head. Four state-of-the-art microcirculation parameters, including peripapillary vessel density (PVD) in the radial peripapillary capillaries (RPC), superficial capillary plexus, deep capillary plexus (DCP), and a choriocapillaris flow void density percentage (CC FVD%) were assessed via swept-source OCTA.

Primary outcomes

Renal func

SUBMITTER: Guo X 

PROVIDER: S-EPMC10587628 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature