Plasma Metabolites Associated with OCT Features of Age-Related Macular Degeneration.

ABSTRACT:

Purpose

The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better characterized by OCT. We and others have shown that patients with AMD have a distinct plasma metabolomic profile compared with controls. However, all studies to date have been performed solely based on CFP classifications. This study aimed to assess if plasma metabolomic profiles are associated with OCT features commonly seen in AMD.

Design

Prospectively designed, cross-sectional study.

Participants

Subjects with a diagnosis of AMD and a control group (> 50 years old) from Boston, United States, and Coimbra, Portugal.

M

SUBMITTER: Lains I 

PROVIDER: S-EPMC10587636 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature