Abscopal effect in metastatic breast cancer treated with stereotactic body radiotherapy in the absence of immunotherapy.

ABSTRACT:

Purpose

In this study, we aimed to assess the abscopal effect (AE) after CyberKnife stereotactic body radiotherapy (SBRT) in metastatic breast cancer patients without immunotherapy.

Methods

We reviewed breast cancer patients who received SBRT with a fraction size of ≥ 6 Gy for metastatic lesions between July 2008 and December 2021. We selected patients who had at least one measurable extracranial lesion in addition to SBRT target lesions and were not treated with immunotherapy. A total of 40 SBRT cases from 34 patients were included in the analysis. The AE was defined as occurring before the overall progression of the disease, regardless of the use of systemic treatment.

Results

The median follow-up duration was 16.4 months. Among 40 SBRT cases, the AE was observed in

SUBMITTER: Kim JS 

PROVIDER: S-EPMC10587686 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature