(Poly)phenols and the regulation of NADPH oxidases.

ABSTRACT: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are enzymes that generate superoxide anion (O₂•^-) and hydrogen peroxide (H₂O₂), and that are widely distributed in mammalian tissues. Many bioactives, especially plant (poly)phenols are being studied for their capacity to regulate NOXs. The modulation of these enzymes are of central relevance to maintain redox homeostasis and regulate cell signaling. In in vitro and ex vivo assays, and in experimental animal models, different (poly)phenols are able to modulate NOX-dependent generation of O₂•^- and H₂O₂. Mechanistically, most of the known effects of (poly)phenols and of their metabolites on NOX1, NOX2, and NOX4, include the modulation of:

SUBMITTER: Fraga CG 

PROVIDER: S-EPMC10587761 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature