YTHDF1 mitigates acute kidney injury via safeguarding m⁶A-methylated mRNAs in stress granules of renal tubules.

ABSTRACT: Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N⁶-methyladenosine (m⁶A) in AKI development, we have investigated m⁶A-modified mRNAs within renal tubular cells subjected to injuries induced by diverse stressors. Notably, while the overall level of m⁶A-modified RNA remains unaltered in renal tubular cells facing stress, a distinct phenomenon emerges-mRNAs bearing m⁶A methylation exhibit a pronounced tendency to accumulate within stress granules (SGs), structures induced in response to these challenges. Cumulation of m⁶A-modified mRNA in SGs is orchestrated by YTHDF1, a m⁶A 'reader' closely associated with SGs. Strikingly, AKI patients and vari

SUBMITTER: Yang W 

PROVIDER: S-EPMC10587769 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature