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Cobalt-assisted route to rare carbocyclic C-ribonucleosides.

ABSTRACT: (Re)emerging RNA viruses have been major threats to public health in the past years, and from the few drugs available, nucleoside analogues are still at the cornerstone of the antiviral therapy. Among them, the synthesis of carbocyclic C-nucleosides is suffering from long syntheses and poor yields. Herein we report a concise stereoselective synthesis of rare carbocyclic C-nucleosides (11a-l) bearing non-canonical nucleobases through a cobalt-assisted-route as key step starting from the optically pure (-)-cyclopentenone 1. This approach paves the route for novel carbocyclic C-nucleoside discovery.

SUBMITTER: Ojeda-Porras AC

PROVIDER: S-EPMC10587889 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Cobalt-assisted route to rare carbocyclic C-ribonucleosides.

Ojeda-Porras A C AC Roy V V Bourzikat O O Favetta P P Agrofoglio L A LA

RSC advances 20231020 44

(Re)emerging RNA viruses have been major threats to public health in the past years, and from the few drugs available, nucleoside analogues are still at the cornerstone of the antiviral therapy. Among them, the synthesis of carbocyclic C-nucleosides is suffering from long syntheses and poor yields. Herein we report a concise stereoselective synthesis of rare carbocyclic C-nucleosides (11a-l) bearing non-canonical nucleobases through a cobalt-assisted-route as key step starting from ...[more]

PMID: 37869399

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