LRRC59 serves as a novel biomarker for predicting the progression and prognosis of bladder cancer.

ABSTRACT:

Background

Leucine-rich repeat-containing protein 59 (LRRC59) is an endoplasmic reticulum membrane protein involved in various cancers, but its role in bladder cancer (BC) has not been reported. The aim of the present study was to investigate the role of LRRC59 protein in BC progression and prognosis.

Methods

The expression profile and clinical significance were retrieved from BC patients in the Cancer Genome Atlas database. The methylation status of LRRC59 was analyzed by UALCAN and MethSurv databases. Potential signaling pathways and biological functions were explored by functional enrichment analysis. Immunocyte infiltration was evaluated by CIBERSORT analysis. The prognostic value of LRRC59 was evaluated by Kaplan-Meier and Cox regression analyses. Overall survival (OS)

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10587936 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature