Assessing the utility of molecular diagnostic classification for cancers of unknown primary.

ABSTRACT:

Background

Roughly 5% of metastatic cancers present with uncertain origin, for which molecular classification could influence subsequent management; however, prior studies of molecular diagnostic classifiers have reported mixed results with regard to clinical impact. In this retrospective study, we evaluated the utility of a novel molecular diagnostic classifier by assessing theoretical changes in treatment and additional testing recommendations from oncologists before and after the review of classifier predictions.

Methods

We retrospectively analyzed de-identified records from 289 patients with a consensus diagnosis of cancer of uncertain/unknown primary (CUP). Two (or three, if adjudication was required) independent oncologists separately reviewed patient clinical informat

SUBMITTER: Moore EC 

PROVIDER: S-EPMC10587948 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature