Precision oncology: Artificial intelligence, circulating cell-free DNA, and the minimally invasive detection of pancreatic cancer-A pilot study.

ABSTRACT:

Background

Pancreatic cancer (PC) is among the most lethal cancers. The lack of effective tools for early detection results in late tumor detection and, consequently, high mortality rate. Precision oncology aims to develop targeted individual treatments based on advanced computational approaches of omics data. Biomarkers, such as global alteration of cytosine (CpG) methylation, can be pivotal for these objectives. In this study, we performed DNA methylation profiling of pancreatic cancer patients using circulating cell-free DNA (cfDNA) and artificial intelligence (AI) including Deep Learning (DL) for minimally invasive detection to elucidate the epigenetic pathogenesis of PC.

Methods

The Illumina Infinium HD Assay was used for genome-wide DNA methylation profiling of cfDNA i

SUBMITTER: Bahado-Singh RO 

PROVIDER: S-EPMC10587955 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature