Four functional profiles for fibre and mucin metabolism in the human gut microbiome.

ABSTRACT:

Background

With the emergence of metagenomic data, multiple links between the gut microbiome and the host health have been shown. Deciphering these complex interactions require evolved analysis methods focusing on the microbial ecosystem functions. Despite the fact that host or diet-derived fibres are the most abundant nutrients available in the gut, the presence of distinct functional traits regarding fibre and mucin hydrolysis, fermentation and hydrogenotrophic processes has never been investigated.

Results

After manually selecting 91 KEGG orthologies and 33 glycoside hydrolases further aggregated in 101 functional descriptors representative of fibre and mucin degradation pathways in the gut microbiome, we used nonnegative matrix factorization to mine metagenomic datasets.

SUBMITTER: Labarthe S 

PROVIDER: S-EPMC10588041 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature