Designs for the simultaneous inference of concentration-response curves.

ABSTRACT:

Background

An important problem in toxicology in the context of gene expression data is the simultaneous inference of a large number of concentration-response relationships. The quality of the inference substantially depends on the choice of design of the experiments, in particular, on the set of different concentrations, at which observations are taken for the different genes under consideration. As this set has to be the same for all genes, the efficient planning of such experiments is very challenging. We address this problem by determining efficient designs for the simultaneous inference of a large number of concentration-response models. For that purpose, we both construct a D-optimality criterion for simultaneous inference and a K-means procedure which clusters the support po

SUBMITTER: Schurmeyer L 

PROVIDER: S-EPMC10588042 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature