Significance of CD103⁺ tissue-resident memory T cells for predicting the effectiveness of immune checkpoint inhibitors in esophageal cancer.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs), including nivolumab, have been approved to treat esophageal cancer. However, these remedies are not fit for all patients with esophageal cancer; therefore, a predictive surrogate marker is needed to assess their effectiveness. CD103⁺CD8⁺ tumor-infiltrating lymphocytes, defined as tissue-resident memory T cells (T_RM), are promising indicators of response to ICIs, but it remains to be elucidated. This study investigated the association between the efficacy of ICIs and T_RM.

Methods

The relationships between T_RM infiltrating esophageal cancer, clinicopathological features, and prognosis after nivolumab initiation were examined using immunostaining. Tissue samples were obtained

SUBMITTER: Natsuki S 

PROVIDER: S-EPMC10588150 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature