Ferroptosis-related lncRNAs guiding osteosarcoma prognosis and immune microenvironment.

ABSTRACT:

Objective

To investigate the ferroptosis-related long non-coding RNAs (FRLncs) implicated in influencing the prognostic and immune microenvironment in osteosarcoma (OS), and to establish a foundational framework for informing clinical decision making pertaining to OS management.

Methods

Transcriptome data and clinical data pertaining to 86 cases of OS, the GSE19276, GSE16088 and GSE33382 datasets, and a list of ferroptosis-related genes (FRGs) were used to establish a risk prognostic model through comprehensive analysis. The identification of OS-related differentially expressed FRGs was achieved through an integrated analysis encompassing the aforementioned 86 OS transcriptome data and the GSE19276, GSE16088 and GSE33382 datasets. Concurrently, OS-related FRLncs were ascerta

SUBMITTER: Yang M 

PROVIDER: S-EPMC10588205 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature