Washed microbiota transplantation improves renal function in patients with renal dysfunction: a retrospective cohort study.

ABSTRACT:

Background

Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota present a potent approach for CKD treatment. This study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT), a modified faecal microbiota transplantation method, on the renal activity of patients with renal dysfunction.

Methods

A comparative analysis of gut microbiota profiles was conducted in patients with renal dysfunction and healthy controls. Furthermore, the efficacy of WMT on renal parameters in patients with renal dysfunction was evaluated, and the changes in gut microbiota and urinary metabolites after WMT treatment were analysed.

Results

Principal coordinate analysis revealed a sign

SUBMITTER: Zhong HJ 

PROVIDER: S-EPMC10588208 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature