A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials.

ABSTRACT:

Background

Perinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth. Despite a growing preclinical evidence base, anti-inflammatory interventions have not been established in clinical practice, partly because of the range of potential targets. We therefore systematically reviewed preclinical studies of immunomodulation to improve neurological outcomes in the perinatal brain and assessed their therapeutic potential.

Methods

We reviewed relevant studies published from January 2012 to July 2023 using PubMed, Medline (OvidSP) and EMBASE databases. Studies were assessed for risk of bias using the SYRCLE risk of bias assessment tool (PROSPERO; registration number CRD42023395690).

Results

Forty prec

SUBMITTER: Kelly SB 

PROVIDER: S-EPMC10588248 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature