Metabolism-related biomarkers, molecular classification, and immune infiltration in diabetic ulcers with validation.

ABSTRACT: Diabetes mellitus (DM) can lead to diabetic ulcers (DUs), which are the most severe complications. Due to the need for more accurate patient classifications and diagnostic models, treatment and management strategies for DU patients still need improvement. The difficulty of diabetic wound healing is caused closely related to biological metabolism and immune chemotaxis reaction dysfunction. Therefore, the purpose of our study is to identify metabolic biomarkers in patients with DU and construct a molecular subtype-specific prognostic model that is highly accurate and robust. RNA-sequencing data for DU samples were obtained from the Gene Expression Omnibus (GEO) database. DU patients and normal individuals were compared regarding the expression of metabolism-related genes (MRGs). Then, a nove

SUBMITTER: Ma XX 

PROVIDER: S-EPMC10588317 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature