Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision.

ABSTRACT: Secreted neuromodulators, like biogenic amines and neuropeptides, can reconfigure circuit functions both locally and at a distance and establish global brain states that alter circuit outputs over prolonged timescales.^1-3 Despite their diversity and ubiquitous presence, many studies on neuromodulation tend to focus on dissecting the function and site of action of individual neuropeptides. Here, we take a different approach by conducting a systems-level investigation of neuropeptide receptor signaling function and cell-type-specific distribution in the context of the Caenorhabditis elegans diapause entry developmental decision. C. elegans diapause entry is controlled by sensory perception of external factors and is regulated by neuropeptide signaling.^4-8 We performed a

SUBMITTER: Chai CM 

PROVIDER: S-EPMC10588560 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature