De novo appearance of cerebral microbleeds in community-dwelling older adults. Neuroimaging and clinical correlates.

ABSTRACT:

Background and purpose

Prospective studies on cerebral microbleeds (CMB) have departed from individuals who already have CMB at baseline. Therefore, main outcomes have usually been the composite of new lesions appearing on the follow-up among patients who already had CMB together with those who de novo developed CMB. Using the Atahualpa Project Cohort, we aimed to assess correlates of incident CMB in community-dwelling older adults free of CMB at baseline.

Methods

Atahualpa residents aged ≥ 60 years received baseline clinical interviews and a brain MRI. Those who were free of CMB at baseline and received follow-up brain MRI at the end of the study were included. Multivariate logistic and Poisson regression models were fitted to assess the association and the incidence rate r

SUBMITTER: Del Brutto OH 

PROVIDER: S-EPMC10588608 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature