Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells.

ABSTRACT: Thymic epithelial cells (TECs) are essential for T cell development in the thymus, yet the mechanisms governing their differentiation are not well understood. Lin28, known for its roles in embryonic development, stem cell pluripotency, and regulating cell proliferation and differentiation, is expressed in endodermal epithelial cells during embryogenesis and persists in adult epithelia, implying postnatal functions. However, the detailed expression and function of Lin28 in TECs remain unknown. In this study, we examined the expression patterns of Lin28 and its target Let-7g in fetal and postnatal TECs and discovered opposing expression patterns during postnatal thymic growth, which correlated with FOXN1 and MHCII expression. Specifically, Lin28b showed high expression i

SUBMITTER: Xiao S 

PROVIDER: S-EPMC10588642 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature