Immune cell abundance and T cell receptor landscapes suggest new patient stratification strategies in head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a molecularly and spatially heterogeneous disease frequently characterized by impairment of immunosurveillance mechanisms. Despite recent success with immunotherapy treatment, disease progression still occurs quickly after treatment in the majority of cases, suggesting the need to improve patient selection strategies. In the quest for biomarkers that may help inform response to checkpoint blockade, we characterized the tumour microenvironment (TME) of 162 HNSCC primary tumours of diverse aetiological and spatial origin, through gene expression and immunohistochemistry (IHC) profiling of relevant immune proteins, T cell receptor (TCR) repertoire analysis and whole-exome sequencing. We identified five HNSCC TME categories based on immune/strom

SUBMITTER: Secrier M 

PROVIDER: S-EPMC10588680 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature