Serum renin and prorenin concentrations predict severe persistent acute kidney injury and mortality in pediatric septic shock.

ABSTRACT:

Background

Studies in critically ill adults demonstrate associations between serum renin concentrations (a proposed surrogate for renin-angiotensin-aldosterone system dysregulation) and poor outcomes, but data in critically ill children are lacking. We assessed serum renin + prorenin concentrations in children with septic shock to determine their predictive ability for acute kidney injury (AKI) and mortality.

Methods

We conducted a secondary analysis of a multicenter observational study of children aged 1 week to 18 years admitted to 14 pediatric intensive care units (PICUs) with septic shock and residual serum available for renin + prorenin measurement. Primary outcomes were development of severe persistent AKI (≥ KDIGO stage 2 for ≥ 48 h) in the first week and 28-day morta

SUBMITTER: Stanski NL 

PROVIDER: S-EPMC10588759 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature