A Systematic Review on Long-Term Efficacy Outcome Measures in Crohn's Disease Patients.

ABSTRACT:

Background

The traditional long-term treatment goal of Crohn's disease [CD] is maintenance of corticosteroid-free clinical remission. Additional treatment targets, such as biochemical, endoscopic and patient-reported remission, are advocated. The relapsing-remitting nature of CD provides a challenge to the timing of target assessment. Cross-sectional assessment at predetermined moments disregards the health state in between measurements. In this systematic review, we provide an overview of outcomes used to assess long-term efficacy in clinical trials in CD.

Methods

A systematic search of the PubMed and EMBASE databases was performed to identify clinical trials in luminal CD reporting on maintenance treatment [strategies] since 1995. Two independent reviewers selected eligibl

SUBMITTER: Janssen LM 

PROVIDER: S-EPMC10588778 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature