Community Types of the Human Gut Virome are Associated with Endoscopic Outcome in Ulcerative Colitis.

ABSTRACT:

Background

Inflammatory bowel disease [IBD] is a major debilitating disease. Recently, the gut microbiota has gained attention as an important factor involved in the pathophysiology of IBD. As a complement to the established bacterial 'enterotypes' associated with IBD, we focused here on viruses. We investigated the intestinal virome of IBD patients undergoing biological therapy for the presence of virome configurations associated with IBD, and to uncover how those configurations are associated with therapeutic success.

Methods

Viral-like particle enrichment followed by deep sequencing was performed on 432 faecal samples from 181 IBD patients starting biological therapy. Redundancy analysis and Dirichlet Multinomial Mixtures were applied to determine covariates of the virome

SUBMITTER: Jansen D 

PROVIDER: S-EPMC10588789 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature