Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients.

ABSTRACT: Immune cells and cytokines are largely recognized as significant factors in the pathophysiology of neuropsychiatric disorders. The possible role of other blood cells such as leukocytes in events of acute psychosis is in contrast only emerging. To study blood-born markers in acute psychosis we here evaluated plasma proteins in drug-naive first-episode psychosis (FEP) patients and healthy controls using a multiplex proximity extension assay technique. We analyzed a panel of 92 immune markers and plasma samples from 60 FEP patients and 50 controls and evaluated the changes obtained using multivariate statistical methods followed by protein pathway analyses. Data showed that 11 proteins are significantly different between FEP patients and healthy controls We observed increases in pro-inflammat

SUBMITTER: Korhonen L 

PROVIDER: S-EPMC10589203 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature