The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria.

ABSTRACT: Culture techniques have associated colonization with pathogenic bacteria in the airways of neonates with later risk of childhood asthma, whereas more recent studies utilizing sequencing techniques have shown the same phenomenon with specific anaerobic taxa. Here, we analyze nasopharyngeal swabs from 1 month neonates in the COPSAC₂₀₀₀ prospective birth cohort by 16S rRNA gene sequencing of the V3-V4 region in relation to asthma risk throughout childhood. Results are compared with previous culture results from hypopharyngeal aspirates from the same cohort and with hypopharyngeal sequencing data from the later COPSAC₂₀₁₀ cohort. Nasopharyngeal relative abundance values of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis are associated with the

SUBMITTER: Thorsen J 

PROVIDER: S-EPMC10589220 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature