Dynamic neural representations of memory and space during human ambulatory navigation.

ABSTRACT: Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one's position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by succ

SUBMITTER: Maoz SLL 

PROVIDER: S-EPMC10589239 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature