Establishment of a novel indicator of pyroptosis regulated gene transcription level and its application in pan-cancer.

ABSTRACT: Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors. Accordingly, we herein established an indicator to evaluate pyroptosis related gene transcription levels based on the expression level of genes involved in pyroptosis and tried to elaborated on the association between pyroptosis and tumors across diverse tumor types. We found that pyroptosis related gene transcription levels could predict the prognosis of patients, which could act as either a favorable or a dreadful factor in diverse cancers. According to signaling pathway analyses we observed that pyroptosis played a significant role in immune

SUBMITTER: Xu JZ 

PROVIDER: S-EPMC10589244 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature