Glycerol-weighted chemical exchange saturation transfer nanoprobes allow ¹⁹F^/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy.

ABSTRACT: Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic. Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still critical for the best therapeutic efficacy of RT. Here we describe pH and O₂ dual-sensitive, perfluorooctylbromide (PFOB)-based and glycerol-weighted chemical exchange saturation transfer (CEST) nano-molecular imaging probes (Gly-PFOBs) with dual fluorine and hydrogen proton based CEST MR imaging properties (¹⁹F/¹H-CEST). Oxygenated Gly-PFOBs ameliorate tumor hypoxia and improve O₂-dependent radiotherapy. Moreover, the pH and O₂ dual-sensitive properties of Gly-PFOBs could be qua

SUBMITTER: A R 

PROVIDER: S-EPMC10589257 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature