Unknown

Dataset Information

0

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.

ABSTRACT: Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST, ID and the NOTCH pathway.

SUBMITTER: Lobon-Iglesias MJ 

PROVIDER: S-EPMC10589300 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.

Lobón-Iglesias María-Jesús MJ   Andrianteranagna Mamy M   Han Zhi-Yan ZY   Chauvin Céline C   Masliah-Planchon Julien J   Manriquez Valeria V   Tauziede-Espariat Arnault A   Turczynski Sandrina S   Bouarich-Bourimi Rachida R   Frah Magali M   Dufour Christelle C   Blauwblomme Thomas T   Cardoen Liesbeth L   Pierron Gaelle G   Maillot Laetitia L   Guillemot Delphine D   Reynaud Stéphanie S   Bourneix Christine C   Pouponnot Célio C   Surdez Didier D   Bohec Mylene M   Baulande Sylvain S   Delattre Olivier O   Piaggio Eliane E   Ayrault Olivier O   Waterfall Joshua J JJ   Servant Nicolas N   Beccaria Kevin K   Dangouloff-Ros Volodia V   Bourdeaut Franck F  

Nature communications 20231020 1

Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-Cre<sup>ERT2</sup>::Smarcb1<sup>flox/flox</sup> model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from  ...[more]

Similar Datasets

Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups
2023-09-20 | GSE242090 | GEO
Methylation profiling Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [DNAmeth_EPICarray]
2023-09-20 | GSE242089 | GEO
Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [bulkRNAseq_primaryATRT]
2023-09-20 | GSE241831 | GEO
Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [scRNAseq_ATRT_CAL]
2023-09-20 | GSE241737 | GEO
Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [scRNAseq_mouseRT_R26SHH]
2023-09-20 | GSE241736 | GEO
Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [bulkRNAseq_mouseRT_R26]
2023-09-20 | GSE241734 | GEO
Transcriptomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [bulkRNAseq_ATRT_cellLines]
2023-09-20 | GSE241733 | GEO
Genomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups
| PRJNA1011311 | ENA
Genomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [bulkRNAseq_primaryATRT]
| PRJNA1010202 | ENA
Genomics Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups [bulkRNAseq_mouseRT_R26]
| PRJNA1009427 | ENA