CD8⁺ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production.

ABSTRACT: Whether CD8⁺ T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non-cytopathic effects, but one hypothesis is that cytopathic effects of CD8⁺ T cells occur before viral production. Here, to examine the role of CD8⁺ T cells prior to virus production, we treated SIVmac251-infected macaques with an integrase inhibitor combined with a CD8-depleting antibody, or with either reagent alone. We analyzed the ensuing viral dynamics using a mathematical model that included infected cells pre- and post- viral DNA integration to compare different immune effector mechanisms. Macaques receiving the integrase inhibitor alone experienced greater viral load decays, reac

SUBMITTER: Policicchio BB 

PROVIDER: S-EPMC10589330 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature