Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α_2A.

ABSTRACT: Innervation of the intestinal mucosa by the sympathetic nervous system is well described but the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal. We therefore investigated the effect of sympathetic neuronal activation on intestinal cells in mouse models and organoid cultures, to identify the molecular routes involved. Using publicly available single-cell RNA sequencing datasets we show that the α_2A isoform is the most abundant adrenergic receptor in small intestinal epithelial cells. Stimulation of this receptor with norepinephrine or a synthetic specific α_2A receptor agonist promotes epithelial proliferation and stem cell function, while reducing differentiation in vivo and in intestinal organoids. In an anastomotic healing mo

SUBMITTER: Ten Hove AS 

PROVIDER: S-EPMC10589335 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature