Prediction of Stroke Outcome in Mice Based on Noninvasive MRI and Behavioral Testing.

ABSTRACT:

Background

Prediction of poststroke outcome using the degree of subacute deficit or magnetic resonance imaging is well studied in humans. While mice are the most commonly used animals in preclinical stroke research, systematic analysis of outcome predictors is lacking.

Methods

We intended to incorporate heterogeneity into our retrospective study to broaden the applicability of our findings and prediction tools. We therefore analyzed the effect of 30, 45, and 60 minutes of arterial occlusion on the variance of stroke volumes. Next, we built a heterogeneous cohort of 215 mice using data from 15 studies that included 45 minutes of middle cerebral artery occlusion and various genotypes. Motor function was measured using a modified protocol for the staircase test of skilled reach

SUBMITTER: Knab F 

PROVIDER: S-EPMC10589430 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature