Cerebrovascular Reactivity in Patients With Small Vessel Disease: A Cross-Sectional Study.

ABSTRACT:

Background

Cerebrovascular reactivity (CVR) is inversely related to white matter hyperintensity severity, a marker of cerebral small vessel disease (SVD). Less is known about the relationship between CVR and other SVD imaging features or cognition. We aimed to investigate these cross-sectional relationships.

Methods

Between 2018 and 2021 in Edinburgh, we recruited patients presenting with lacunar or cortical ischemic stroke, whom we characterized for SVD features. We measured CVR in subcortical gray matter, normal-appearing white matter, and white matter hyperintensity using 3T magnetic resonance imaging. We assessed cognition using Montreal Cognitive Assessment. Statistical analyses included linear regression models with CVR as outcome, adjusted for age, sex, and vascular r

SUBMITTER: Sleight E 

PROVIDER: S-EPMC10589433 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature