Small RNA sequencing of exosomal microRNAs reveals differential expression of microRNAs in preeclampsia.

ABSTRACT: Preeclampsia (PE) is one of the most common hypertensive disorders of pregnancy. It is a dangerous condition with a high mortality rate in mothers and fetuses and is associated with a lack of early diagnosis and effective treatment. While the etiology of the disease is complex and obscure, it is now clear that the placenta is central to disease progression. Exosomal microRNAs (miRNAs) are possible mediators that regulate placenta-related physiological and pathological processes. Placental mesenchymal stem cells have considerable potential to help us understand the pathogenesis and treatment of pregnancy-related diseases. Here, we investigate the exosomal miRNA profiles of human placenta-derived mesenchymal stem cells between healthy pregnant women and those with PE. We performed small RNA

SUBMITTER: Ning H 

PROVIDER: S-EPMC10589583 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature