Activity of estrogen receptor β expressing neurons in the medial amygdala regulates preference toward receptive females in male mice.

ABSTRACT: The processing of information regarding the sex and reproductive state of conspecific individuals is critical for successful reproduction and survival in males. Generally, male mice exhibit a preference toward the odor of sexually receptive (RF) over nonreceptive females (XF) or gonadally intact males (IM). Previous studies suggested the involvement of estrogen receptor beta (ERβ) expressed in the medial amygdala (MeA) in male preference toward RF. To further delineate the role played by ERβ in the MeA in the neuronal network regulating male preference, we developed a new ERβ-iCre mouse line using the CRISPR-Cas9 system. Fiber photometry Ca²⁺ imaging revealed that ERβ-expressing neurons in the postero-dorsal part of the MeA (MeApd-ERβ⁺ neurons) were more active during

SUBMITTER: Takenawa S 

PROVIDER: S-EPMC10589649 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature