Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor.

ABSTRACT: Bacteria possess various receptors that sense different signals and transmit information to enable an optimal adaptation to the environment. A major limitation in microbiology is the lack of information on the signal molecules that activate receptors. Signals recognized by sensor domains are poorly reflected in overall sequence identity, and therefore, the identification of signals from the amino acid sequence of the sensor alone presents a challenge. Biogenic amines are of great physiological importance for microorganisms and humans. They serve as substrates for aerobic and anaerobic growth and play a role of neurotransmitters and osmoprotectants. Here, we report the identification of a sequence motif that is specific for amine-sensing sensor domains that belong to the Cache superfamily o

SUBMITTER: Cerna-Vargas JP 

PROVIDER: S-EPMC10589655 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature