Cellular migration into a subretinal honeycomb-shaped prosthesis for high-resolution prosthetic vision.

ABSTRACT: In patients blinded by geographic atrophy, a subretinal photovoltaic implant with 100 µm pixels provided visual acuity closely matching the pixel pitch. However, such flat bipolar pixels cannot be scaled below 75 µm, limiting the attainable visual acuity. This limitation can be overcome by shaping the electric field with 3-dimensional (3-D) electrodes. In particular, elevating the return electrode on top of the honeycomb-shaped vertical walls surrounding each pixel extends the electric field vertically and decouples its penetration into tissue from the pixel width. This approach relies on migration of the retinal cells into the honeycomb wells. Here, we demonstrate that majority of the inner retinal neurons migrate into the 25 µm deep wells, leaving the third-order neurons, such as amacrin

SUBMITTER: Bhuckory MB 

PROVIDER: S-EPMC10589669 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature