White matter changes measured by multi-component MR Fingerprinting in multiple sclerosis.

ABSTRACT: T₂-hyperintense lesions are the key imaging marker of multiple sclerosis (MS). Previous studies have shown that the white matter surrounding such lesions is often also affected by MS. Our aim was to develop a new method to visualize and quantify the extent of white matter tissue changes in MS based on relaxometry properties. We applied a fast, multi-parametric quantitative MRI approach and used a multi-component MR Fingerprinting (MC-MRF) analysis. We assessed the differences in the MRF component representing prolongedrelaxation time between patients with MS and controls and studied the relation between this component's volume and structural white matter damage identified on FLAIR MRI scans in patients with MS. A total of 48 MS patients at two different sites and 12 healthy cont

SUBMITTER: Nagtegaal MA 

PROVIDER: S-EPMC10589890 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature