Re-stratification of patients with copy-number low endometrial cancer by clinicopathological characteristics.

ABSTRACT:

Objective

To stratify patients with copy-number low (CNL) endometrial cancer (EC) by clinicopathological characteristics.

Methods

EC patients who underwent surgery between June 2018 and June 2022 at Peking University People's Hospital were included and further classified according to TCGA molecular subtyping: POLE ultramutated, microsatellite instability high (MSI-H), CNL, and copy-number high (CNH). Clinicopathological characteristics and prognosis of CNL patients were retrospectively reviewed. The Cox proportional hazards regression model was applied to perform univariate and multivariate analysis, and independent risk factors were identified. Differentially expressed genes (DEGs) according to overall survival (OS) were screened based on the transcriptome of CNL cases from

SUBMITTER: Liwei L 

PROVIDER: S-EPMC10589940 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature