Network pharmacology-based strategy to investigate the effect and mechanism of α-solanine against glioma.

ABSTRACT:

Background

An anti-tumour activity has been demonstrated for α-solanine, a bioactive compound extracted from the traditional Chinese herb Solanum nigrum L. However, its efficacy in the treatment of gliomas and the underlying mechanisms remain unclear. The aim of this study was to investigate the inhibitory effects of α-solanine on glioma and elucidate its mechanisms and targets using network pharmacology, molecular docking, and molecular biology experiments.

Methods

Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was utilized to predict the potential targets of α-solanine. GeneCards was used to gather glioma-related targets, and the STRING online database was used to analyze protein-protein interaction (PPI) networks for the shared ta

SUBMITTER: Wang C 

PROVIDER: S-EPMC10589944 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature