The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.

ABSTRACT:

Background

The flatworm planarian, Schmidtea mediterranea, has a large population of adult stem cells (ASCs) that replace any cell type during tissue turnover or regeneration. How planarian ASCs (called neoblasts) manage self-renewal with the ability to produce daughter cells of different cell lineages (multipotency) is not well understood. Chromatin remodeling complexes ultimately control access to DNA regions of chromosomes and together with specific transcription factors determine whether a gene is transcribed in a given cell type. Previous work in planarians determined that RNAi of core components of the BAF chromatin remodeling complex, brg1 and smarcc2, caused increased ASCs and failed regeneration, but how these cellular defects arise at the level of gene regulation in neobl

SUBMITTER: Wiggans M 

PROVIDER: S-EPMC10589948 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature