Conditional diagnostic accuracy according to inflammation status and age for diagnosing tuberculous effusion.

ABSTRACT:

Background

Tuberculous effusion varies from lymphocyte-dominant to neutrophilic effusion according to inflammation status. The criteria of adenosine deaminase (ADA) and lymphocyte/neutrophil (L/N) ratio have yet not been evaluated across different disease conditions.

Methods

Patients who conducted pleural fluid analysis from 2009 to 2019 at Asan Medical Center were included. Criteria (ADA of 50 and L/N ratio of 0.75) were evaluated by quantile subgroups according to age, C-reactive protein (CRP), white blood cell (WBC), and lactate dehydrogenase (LD) by the Monte Carlo simulation method to diagnose tuberculosis. The model for the ADA and L/N ratio was evaluated by AUROC.

Results

Among the 2,918 reviewed cases, 2034 were included with 229 (11.26%) tuberculosis cases. T

SUBMITTER: Jeon DS 

PROVIDER: S-EPMC10589957 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature